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The $BRAF^{V600E}$ Mutation Is Not a Risk Factor for More Aggressive Tumor Behavior in Radiogenic and Sporadic Papillary Thyroid Carcinoma at a Young Age
| Content Provider | MDPI |
|---|---|
| Author | Zurnadzhy, Liudmyla Bogdanova, Tetiana Rogounovitch, Tatiana I. Ito, Masahiro Tronko, Mykola Yamashita, Shunichi Mitsutake, Norisato Chernyshov, Serhii Masiuk, Sergii Saenko, Vladimir A. |
| Copyright Year | 2021 |
| Description | Histopathological changes in the fusion oncogene-driven papillary thyroid carcinomas (PTCs) from children and adolescents exposed to Chernobyl fallout have been extensively studied. However, characteristics of the radiogenic $BRAF^{V600E}$-positive PTCs, whose proportion is growing with time, are not well described yet. We analyzed the relationship between the $BRAF^{V600E}$ status (determined immunohistochemically with the VE1 antibody) and the clinicopathological features of 247 radiogenic and 138 sporadic PTCs from young Ukrainian patients aged ≤28 years. The frequency of $BRAF^{V600E}$ was increasing with patient age, consistently remaining lower in radiogenic PTCs. In both etiopathogenic groups, the $BRAF^{V600E}$-positive PTCs more frequently had a dominant papillary growth pattern, smaller tumor size, higher Ki67 labeling index, and a frequency of the major indicators of tumor invasiveness that is lower than or equal to that of the $BRAF^{V600E}$-negative tumors. Comparison of the $BRAF^{V600E}$-positive PTCs across the groups found a virtual absence of differences. In contrast, the $BRAF^{V600E}$-negative radiogenic PTCs displayed less frequent dominant papillary and more frequent solid growth patterns, lower Ki67 labeling index, and higher invasiveness than the $BRAF^{V600E}$-negative sporadic tumors. Thus, $BRAF^{V600E}$ is not associated with a more aggressive course of PTC in young patients regardless of etiology. The major clinicopathological differences between the radiogenic and sporadic PTCs are observed among the $BRAF^{V600E}$-negative tumors. |
| Starting Page | 6038 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13236038 |
| Journal | Cancers |
| Issue Number | 23 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-11-30 |
| Access Restriction | Open |
| Subject Keyword | Cancers Endocrinology and Metabolism Papillary Thyroid Carcinoma Brafv600e Chernobyl Immunohistochemistry Ve1 Antibody Ki67 Labeling Index |
| Content Type | Text |
| Resource Type | Article |
