NDLI: Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

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Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

Content Provider	MDPI
Author	Karolina, Stępień O’Connor, Kevin Pekmezovic, Marina Krusic, Melina Kalagasidis Malagurski, Ivana Milovanovic, Jelena Guzik, Maciej Charifou, Romina Babu, Ramesh Nikodinovic-Runic, Jasmina
Copyright Year	2021
Description	Novel biodegradable and biocompatible formulations of “old” but “gold” drugs such as nystatin (Nys) and amphotericin B (AmB) were made using a biopolymer as a matrix. Medium chain length polyhydroxyalkanoates (mcl-PHA) were used to formulate both polyenes (Nys and AmB) in the form of films (~50 µm). Thermal properties and stability of the materials were not significantly altered by the incorporation of polyenes in mcl-PHA, but polyene containing materials were more hydrophobic. These formulations were tested in vitro against a panel of pathogenic fungi and for antibiofilm properties. The films containing 0.1 to 2 weight % polyenes showed good activity and sustained polyene release for up to 4 days. A PHA monomer, namely 3-hydroxydecanoic acid (C10-OH), was added to the films to achieve an enhanced synergistic effect with polyenes against fungal growth. Mcl-PHA based polyene formulations showed excellent growth inhibitory activity against both Candida yeasts (C. albicans ATCC 1023, C. albicans SC5314 (ATCC MYA-2876), C. parapsilosis ATCC 22019) and filamentous fungi (Aspergillus fumigatus ATCC 13073; Trichophyton mentagrophytes ATCC 9533, Microsporum gypseum ATCC 24102). All antifungal PHA film preparations prevented the formation of a C. albicans biofilm, while they were not efficient in eradication of mature biofilms, rendering them suitable for the transdermal application or as coatings of implants.
Starting Page	737
e-ISSN	20796382
DOI	10.3390/antibiotics10060737
Journal	Antibiotics
Issue Number	6
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-06-18
Access Restriction	Open
Subject Keyword	Antibiotics Mycology Polyhydroxyalkanoate Film Antifungal 3-hydroxydecanoic Acid Polyene Nystatin Amphotericin B Candida
Content Type	Text
Resource Type	Article

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