NDLI: Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM

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Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM

Content Provider	MDPI
Author	Pasquini, Luca Napolitano, Antonio Tagliente, Emanuela Dellepiane, Francesco Lucignani, Martina Vidiri, Antonello Ranazzi, Giulio Stoppacciaro, Antonella Moltoni, Giulia Nicolai, Matteo Romano, Andrea Bozzao, Alessandro
Copyright Year	2021
Description	Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. Deep learning showed promising results for IDH identification in mixed low/high grade glioma populations; however, a GBM-specific model is still lacking in the literature. Our aim was to develop a GBM-tailored deep-learning model for IDH prediction by applying convoluted neural networks (CNN) on multiparametric MRI. We selected 100 adult patients with pathologically demonstrated WHO grade IV gliomas and IDH testing. MRI sequences included: MPRAGE, T1, T2, FLAIR, rCBV and ADC. The model consisted of a 4-block 2D CNN, applied to each MRI sequence. Probability of IDH mutation was obtained from the last dense layer of a softmax activation function. Model performance was evaluated in the test cohort considering categorical cross-entropy loss (CCEL) and accuracy. Calculated performance was: rCBV (accuracy 83%, CCEL 0.64), T1 (accuracy 77%, CCEL 1.4), FLAIR (accuracy 77%, CCEL 1.98), T2 (accuracy 67%, CCEL 2.41), MPRAGE (accuracy 66%, CCEL 2.55). Lower performance was achieved on ADC maps. We present a GBM-specific deep-learning model for IDH mutation prediction, with a maximal accuracy of 83% on rCBV maps. Highest predictivity achieved on perfusion images possibly reflects the known link between IDH and neoangiogenesis through the hypoxia inducible factor.
Starting Page	290
e-ISSN	20754426
DOI	10.3390/jpm11040290
Journal	Journal of Personalized Medicine
Issue Number	4
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-04-09
Access Restriction	Open
Subject Keyword	Journal of Personalized Medicine Oncology Gbm High Grade Glioma Mri Idh Deep Learning Cbv Artificial Intelligence
Content Type	Text
Resource Type	Article

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