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Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
| Content Provider | MDPI |
|---|---|
| Author | Savastano, Maria Cristina Rizzo, Clara Gambini, Gloria Savastano, Alfonso Falsini, Benedetto Bacherini, Daniela Caputo, Carmela Grazia Kilian, Raphael Faraldi, Francesco Vico, Umberto De Rizzo, Stanislao |
| Copyright Year | 2021 |
| Description | Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measurements of whole image choriocapillaris VD (%) and fovea grid-based (%) were collected for the analysis. Angio-View patterns were used to assess the flow area $(mm^{2}$) of macular neovascularization (MNV) by contour flow measure algorithm. Best-corrected visual acuity (BCVA) of both groups was also used for the statistical analysis. Results: The mean age was 60.9 (±8.3) in healthy and 73.33 (±15.05) in ae-AMD eyes. The mean BCVA (ETDRS letters) was 98.47 (±1.50) in healthy and 7.04 (±5.96) in ae-AMD eyes. The Mann–Whitney test comparing choriocapillaries VD for whole and fovea healthy and ae-AMD eyes showed statistical significance (p < 0.0001 (t = 4.91; df = 40) and p < 0.0001 (t = 6.84; df = 40), respectively). Regarding, the correlation between MNV and VD of choriocapillaries, neither whole nor fovea areas were statistically significant (F = 0.38 $(R^{2}$ = 0.01) and 1.68 $(R^{2}$ = 0.08), respectively). Conclusions: Choriocapillaris VD showed a statistically significant reduction in comparison to healthy eyes in ae-AMD eyes. Choriocapillaris impairment can be seen in the early phase of MNV pathogenesis. |
| Starting Page | 1958 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11111958 |
| Journal | Diagnostics |
| Issue Number | 11 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-10-22 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Ophthalmology Advanced Exudative Amd Age-related Macular Degeneration Innovative Biotechnologies Macular Neovascularization Oct Angiography Personalized Medicine Biomarkers |
| Content Type | Text |
| Resource Type | Article |
