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Trichuris muris Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense
| Content Provider | MDPI |
|---|---|
| Author | Yousefi, Yeganeh Haq, Sabah Banskota, Suhrid Kwon, Yun Khan, Waliul |
| Copyright Year | 2021 |
| Description | Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. Trichuris trichiura is one of the world’s most common intestinal parasites that causes human parasitic infections. Trichuris muris, as an immunologically well-defined mouse model of T. trichiura, is extensively used to study different aspects of the innate and adaptive components of the immune system. Studies on T. muris model offer insights into understanding host immunity, since this parasite generates two distinct immune responses in resistant and susceptible strains of mouse. Apart from the immune cells, T. muris infection also influences various components of the intestinal tract, especially the gut microbiota, mucus layer, epithelial cells and smooth muscle cells. Here, we reviewed the different immune responses generated by innate and adaptive immune components during acute and chronic T. muris infections. Furthermore, we discussed the importance of studying T. muris model in understanding host–parasite interaction in the context of alteration in the host’s microbiota, intestinal barrier, inflammation, and host defense, and in parasite infection-mediated modulation of other immune and inflammatory diseases. |
| Starting Page | 925 |
| e-ISSN | 20760817 |
| DOI | 10.3390/pathogens10080925 |
| Journal | Pathogens |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-22 |
| Access Restriction | Open |
| Subject Keyword | Pathogens Immunology Infectious Diseases Intestinal Helminth Trichuris Muris Immune Response Host–parasite Interaction Host Defense Epithelial Cells Goblet Cells Enteroendocrine Cells Smooth Muscle Cells |
| Content Type | Text |
| Resource Type | Article |
