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An Unexpected Reaction of Isodehydracetic Acid with Amines in the Presence of 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride Yields a New Type of β-Enaminones
| Content Provider | MDPI |
|---|---|
| Author | Wang, Delong Shi, Hui |
| Copyright Year | 2020 |
| Description | The reaction of isodehydracetic acid with amines was serendipitously found to afford β-enaminones in the presence of the coupling agent 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Under the optimal reaction condition, 23 examples of α-aminomethylene glutaconic anhydride were obtained at approximately 30−80% yields. This is a concise, operationally simple method to expediently synthesize a new type of β-enaminone-containing compound. |
| Starting Page | 2131 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules25092131 |
| Journal | Molecules |
| Issue Number | 9 |
| Volume Number | 25 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-02 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Isodehydracetic Acid Edc Ketene |
| Content Type | Text |
| Resource Type | Article |
