Loading...
Please wait, while we are loading the content...
Similar Documents
Unexpected Outcomes of Renal Function after Radical Nephrectomy: Histology Relevance along with Clinical Aspects
| Content Provider | MDPI |
|---|---|
| Author | Giacomo, Dell’Antonio Marco, Federico Di Pani, Antonello Floris, Matteo Martini, Alberto Capitanio, Umberto Bettiga, Arianna Larcher, Alessandro Cinque, Alessandra Bertini, Roberto Briganti, Alberto Salonia, Andrea Montorsi, Francesco Trevisani, Francesco |
| Copyright Year | 2021 |
| Description | Acute kidney injury (AKI) and chronic kidney disease (CKD) are common events after radical nephrectomy (RN). In this study we aimed to predict AKI and CKD after RN relying on specific histological aspects. We collected data from a cohort of 144 patients who underwent radical nephrectomy. A histopathological review of the healthy part of the removed kidney was performed using an established chronicity score (CS). Logistic regression analyses were performed to predict AKI after RN, while linear regression analysis was adopted for estimated glomerular filtration rate (eGFR) variation at 1 year. The outcomes of the study were to determine variables correlated with AKI onset, and with eGFR decay at 1 year. The proportion of AKI was 64%. Logistic analyses showed that baseline eGFR independently predicted AKI (odds ratio 1.04, 95%CI 1.02:1.06). Moreover, AKI (Beta −16, 95%CI −21:−11), baseline eGFR (Beta −0.42, 95%CI −0.52:−0.33), and the presence of arterial narrowing (Beta 10, 95%CI 4:15) were independently associated with eGFR decline. Our findings showed that AKI onset and eGFR decline were more likely to occur with higher baseline eGFR and lower CS, highlighting that RN in normal renal function patients represents a more traumatic event than its CKD counterpart. |
| Starting Page | 3322 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm10153322 |
| Journal | Journal of clinical medicine |
| Issue Number | 15 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-28 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Urology and Nephrology Aki Ckd Egfr Radical Nephrectomy Renal Pathology |
| Content Type | Text |
| Resource Type | Article |
