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Dynamic Contrast-Enhanced and Intravoxel Incoherent Motion MRI Biomarkers Are Correlated to Survival Outcome in Advanced Hepatocellular Carcinoma
| Content Provider | MDPI |
|---|---|
| Author | Chen, Bang-Bin Shao, Yu-Yun Lin, Zhong-Zhe Hsu, Chih-Hung Cheng, Ann-Lii Hsu, Chiun Liang, Po-Chin Shih, Tiffany |
| Copyright Year | 2021 |
| Description | Objective: This study assessed dynamic contrast-enhanced (DCE)-MRI and intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) parameters to prospectively predict survival outcomes in participants with advanced hepatocellular carcinoma (HCC) who received lenalidomide, a dual antiangiogenic and immunomodulatory agent, as second-line therapy in a Phase II clinical trial. Materials and methods: Forty-four participants with advanced HCC who had progression after sorafenib as first-line treatment were prospectively enrolled. Pretreatment MRI parameters—obtained from DCE-MRI (peak, slope, AUC, $K^{trans}$, $K_{ep}$, and $V_{e}$), apparent diffusion coefficient (ADC), and IVIM DWI (pure diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f))—were derived from the largest hepatic tumor. The Cox model was used to investigate the associations of the parameters with progression-free survival (PFS) and overall survival (OS). Results: Median PFS and OS were 2.3 and 8.0 months, respectively. Univariate analysis showed that participants with a high slope (p = 0.024), $K_{ep}$ (p < 0.001), and ADC (p = 0.018) values had longer PFS than those with low values; participants with a small tumor size (p = 0.006), high slope (p = 0.01), ADC (p = 0.015), and f (p = 0.012) values had longer OS than those with low values did. Cox multivariable analysis revealed that $K_{ep}$ (p < 0.001) and ADC (p = 0.009) remained independent predictors of PFS; slope (p = 0.003) and ADC (p = 0.009) remained independent predictors of OS. Moreover, $K_{ep}$ and slope were still significant after Bonferroni correction was performed (p < 0.005). Conclusion: Both pretreatment DCE-MRI and IVIM DWI parameters, especially slope and ADC, may predict PFS and OS in participants with HCC receiving lenalidomide as second-line therapy. |
| Starting Page | 1340 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11081340 |
| Journal | Diagnostics |
| Issue Number | 8 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-26 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Oncology Magnetic Resonance Angiography Diffusion Mri Hepatocellular Carcinoma Survival Lenalidomide |
| Content Type | Text |
| Resource Type | Article |
