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Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
| Content Provider | MDPI |
|---|---|
| Author | Mar, Quiñones Eva, Martínez-Grobas Raquel, Pérez-Lois Ferno, Johan Seoane, Luisa Massadi, Omar Al |
| Copyright Year | 2021 |
| Description | Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balance. |
| Starting Page | 1430 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms22031430 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 3 |
| Volume Number | 22 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-31 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Endocrinology and Metabolism Keywords: Sirt1 Sirt6 Energy Balance Food Intake Body Weight Adiposity Type 2 Diabetes Obesity |
| Content Type | Text |
| Resource Type | Article |
