NDLI: Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen

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Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen

Content Provider	MDPI
Author	Ueda, Shoko Ito, Jun Harada, Norihiro Harada, Sonoko Sasano, Hitoshi Sandhu, Yuuki Tanabe, Yuki Abe, Sumiko Shiota, Satomi Kodama, Yuzo Nagaoka, Tetsutaro Makino, Fumihiko Chiba, Asako Akiba, Hisaya Atsuta, Ryo Miyake, Sachiko Takahashi, Kazuhisa
Copyright Year	2022
Description	Allergen immunotherapy is a promising treatment for allergic diseases that induce immune tolerance through the administration of specific allergens. In this study, we investigate the efficacy of sublingual immunotherapy (SLIT) in asthmatic patients with SAR-JCP and the dynamics of the parameters before and after treatment in a real-world setting. This was a prospective single-center observational study. Patients with asthma and SAR-JCP (n = 24) were recruited for this study and assessed using symptom questionnaires before SLIT and a year after the SLIT. In addition, a respiratory function test, forced oscillation technique, and blood sampling test were performed during the off-season before and after SLIT. The one-year SLIT for asthma patients with SAR-JCP significantly improved not only allergic rhinitis symptoms, but also asthma symptoms during the JCP dispersal season, and significantly improved airway resistance during the off-season. The change in the asthma control test and the visual analog scale score during the season before and after SLIT was negatively and positively correlated with the change in peripheral blood γδ T cells off-season before and after SLIT, respectively. It was suggested that improvement in asthma symptoms during the JCP dispersal season after SLIT was associated with reduced peripheral blood γδ T cells.
Starting Page	518
e-ISSN	2218273X
DOI	10.3390/biom12040518
Journal	Biomolecules
Issue Number	4
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-03-29
Access Restriction	Open
Subject Keyword	Biomolecules Allergy Japanese Cedar Pollen Seasonal Allergic Rhinitis Asthma Sublingual Immunotherapy Japanese Cedar Pollinosis
Content Type	Text
Resource Type	Article

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