NDLI: The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

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The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

Content Provider	MDPI
Author	D’Erasmo, Laura Bini, Simone Costanzo, Alessia Di Minicocci, Ilenia Pecce, Valeria Arca, Marcello
Copyright Year	2021
Description	Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
Starting Page	742
e-ISSN	14220067
DOI	10.3390/ijms22020742
Journal	International Journal of Molecular Sciences
Issue Number	2
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-01-13
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Endocrinology and Metabolism Adipose Tissue Adiposopathy Brown Adipose Tissue Angptl3 Angptl4 Angptl8
Content Type	Text
Resource Type	Article

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