NDLI: Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass (Micropterus salmoides) Based on Integrated Lipidomics and Proteomics

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Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass (Micropterus salmoides) Based on Integrated Lipidomics and Proteomics

Content Provider	MDPI
Author	Xue, Moyong Yao, Ting Xue, Min Francis, Frédéric Qin, Yuchang Jia, Ming Li, Junguo Gu, Xu
Copyright Year	2022
Description	Metabolic fatty liver disease caused by high-starch diet restricted the intensive and sustainable development of carnivorous fish such as largemouth bass. In this study, the combination liver proteomic and lipidomic approach was employed to investigate the key signaling pathways and identify the critical biomarkers of fatty liver in largemouth bass. Joint analysis of the correlated differential proteins and lipids revealed nine common metabolic pathways; it was determined that FABP1 were significantly up-regulated in terms of transporting more triglycerides into the liver, while ABCA1 and VDAC1 proteins were significantly down-regulated in terms of preventing the transport of lipids and cholesterol out of the liver, leading to triglyceride accumulation in hepatocyte, eventually resulting in metabolic fatty liver disease. The results indicate that FABP1, ABCA1 and VDAC1 could be potential biomarkers for treating metabolic fatty liver disease of largemouth bass.
Starting Page	759
e-ISSN	22181989
DOI	10.3390/metabo12080759
Journal	Metabolites
Issue Number	8
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-08-17
Access Restriction	Open
Subject Keyword	Metabolites Biochemical Research Metabolic Liver Disease Integrated Analysis Proteomics Lipidomics Largemouth Bass
Content Type	Text
Resource Type	Article

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