NDLI: Invasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients

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Invasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients

Content Provider	MDPI
Author	Raffaelli, Francesca Tanzarella, Eloisa Sofia Pascale, Gennaro De Tumbarello, Mario
Copyright Year	2022
Description	Patients with coronavirus disease 19 (COVID-19) admitted to the intensive care unit (ICU) often develop respiratory fungal infections. The most frequent diseases are the COVID-19 associated pulmonary aspergillosis (CAPA), COVID-19 associated pulmonary mucormycosis (CAPM) and the Pneumocystis jirovecii pneumonia (PCP), the latter mostly found in patients with both COVID-19 and underlying HIV infection. Furthermore, co-infections due to less common mold pathogens have been also described. Respiratory fungal infections in critically ill patients are promoted by multiple risk factors, including epithelial damage caused by COVID-19 infection, mechanical ventilation and immunosuppression, mainly induced by corticosteroids and immunomodulators. In COVID-19 patients, a correct discrimination between fungal colonization and infection is challenging, further hampered by sampling difficulties and by the low reliability of diagnostic approaches, frequently needing an integration of clinical, radiological and microbiological features. Several antifungal drugs are currently available, but the development of new molecules with reduced toxicity, less drug-interactions and potentially active on difficult to treat strains, is highly warranted. Finally, the role of prophylaxis in certain COVID-19 populations is still controversial and must be further investigated.
Starting Page	415
e-ISSN	2309608X
DOI	10.3390/jof8040415
Journal	Journal of Fungi
Issue Number	4
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2022-04-17
Access Restriction	Open
Subject Keyword	Journal of Fungi Infectious Diseases Covid-19 Sars-cov-2 Respiratory Fungal Infection Capa Pneumocystosis Cam
Content Type	Text
Resource Type	Article

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