NDLI: Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer

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Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer

Content Provider	MDPI
Author	Migliaccio, Ilenia Leo, Angela Galardi, Francesca Guarducci, Cristina Fusco, Giulio Benelli, Matteo Leo, Angelo Di Biganzoli, Laura Malorni, Luca
Copyright Year	2021
Description	CDK4/6 inhibitors (CDK4/6i) and endocrine therapy are the standard treatment for patients with hormone receptor-positive and HER2 negative (HR+/HER2−) metastatic breast cancer. Patients might show intrinsic and acquired resistance, which leads to treatment failure and progression. Circulating biomarkers have the potential advantages of recognizing patients who might not respond to treatment, monitoring treatment effects and identifying markers of acquired resistance during tumor progression with a simple withdrawal of peripheral blood. Genomic alterations on circulating tumor DNA and serum thymidine kinase activity, but also circulating tumor cells, epigenetic or exosome markers are currently being tested as markers of CDK4/6i treatment response, even though none of these have been integrated into clinical practice. In this review, we discuss the recent advancements in the development of circulating biomarkers of CDK4/6i response in patients with HR+/HER2−breast cancer.
Starting Page	2640
e-ISSN	20726694
DOI	10.3390/cancers13112640
Journal	Cancers
Issue Number	11
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-05-27
Access Restriction	Open
Subject Keyword	Cancers Endocrinology and Metabolism Cdk4/6 Inhibitors Circulating Biomarkers Liquid Biopsy Therapy Resistance Breast Cancer
Content Type	Text
Resource Type	Article

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