Loading...
Please wait, while we are loading the content...
Similar Documents
Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase
| Content Provider | MDPI |
|---|---|
| Author | Isabel, López-Martín Juan, García-Soriano Antonio, Jiménez-Ruiz Sonsoles, Velázquez Revuelto, Alejandro de Lucio, Héctor Zanda, Nicola de Castro, Sonia Gago, Federico Camarasa, María-José |
| Copyright Year | 2021 |
| Description | Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept that disrupting protein–protein interactions at the dimer interface of Leishmania infantum TryR (LiTryR) offered an innovative and so far unexploited opportunity for the development of novel antileishmanial agents. Now, we show that linking our previous peptide prototype TRL38 to selected hydrophobic moieties provides a novel series of small-molecule–peptide conjugates that behave as good inhibitors of both LiTryR activity and dimerization. |
| Starting Page | 689 |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph14070689 |
| Journal | Pharmaceuticals |
| Issue Number | 7 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-17 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceuticals Leishmaniasis Small Molecule–peptide Conjugates Dimerization Inhibitors Trypanothione Disulfide Reductase |
| Content Type | Text |
| Resource Type | Article |
