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Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines
| Content Provider | MDPI |
|---|---|
| Author | Stanis, ław Leśniak Buchcic, Aleksandra Zawisza, Anna Rachwalski, Michał |
| Copyright Year | 2020 |
| Description | Over the course of the present studies, a series of optically pure phosphines functionalized by chiral aziridines was synthesized in reasonable/good chemical yields. Their catalytic activity was checked in the enantioselective Friedel–Crafts alkylation of indoles by β-nitrostyrene in the presence of a copper(I) trifluoromethanesulfonate benzene complex. The corresponding Friedel–Crafts products were achieved efficiently in terms of chemical yield and enantioselectivity (up to 85% in some cases). |
| Starting Page | 971 |
| e-ISSN | 20734344 |
| DOI | 10.3390/catal10090971 |
| Journal | Catalysts |
| Issue Number | 9 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-08-26 |
| Access Restriction | Open |
| Subject Keyword | Catalysts Organic Chemistry Asymmetric Transformations Chiral Aziridinyl-phosphines Enantioselective Friedel–crafts Alkylation Stereoselectivity |
| Content Type | Text |
| Resource Type | Article |
