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Performance of Heart Failure Patients with Severely Reduced Ejection Fraction during Cardiopulmonary Exercise Testing on Treadmill and Cycle Ergometer; Similarities and Differences
| Content Provider | MDPI |
|---|---|
| Author | Mazaheri, Reza Sadeghian, Mohammad Nazarieh, Mahshid Niederseer, David Schmied, Christian |
| Copyright Year | 2021 |
| Description | Background: Peak oxygen consumption $(VO_{2}$) measured by cardiopulmonary exercise testing (CPET) is a significant predictor of mortality and future transplantation in heart failure patients with severely reduced ejection fraction (HFrEF). The present study evaluated the differences in peak $VO_{2}$ and other prognostic variables between treadmill and cycle CPETs in these patients. Methods: In this cross-over study design, thirty males with severe HFrEF underwent CPET on both a treadmill and a cycle ergometer within 2–5 days apart, and important CPET parameters between two exercise test modalities were compared. Results: Peak $VO_{2}$ was 23.12% higher on the treadmill than on cycle (20.55 ± 3.3 vs. 16.69 ± 3.01, p < 0.001, respectively). Minute ventilation to carbon dioxide production $(VE/VCO_{2}$) slope was not different between the two CPET modes (p = 0.32). There was a strong positive correlation between the $VE/VCO_{2}$ slopes during treadmill and cycle testing (r = 0.79; p < 0.001). $VE/VCO_{2}$ slope was not related to peak respiratory exchange ratio (RER) in either modality (treadmill, r = 0.13, p = 0.48; cycle, r = 0.25, p = 0.17). The RER level was significantly higher on the cycle ergometer (p < 0.001). Conclusion: Peak $VO_{2}$ is higher on treadmill than on cycle ergometer in severe HFrEF patients. In addition, $VE/VCO_{2}$ slope is not a modality dependent parameter and is not related to the patients’ effort during CPET. |
| Starting Page | 12958 |
| e-ISSN | 16604601 |
| DOI | 10.3390/ijerph182412958 |
| Journal | International Journal of Environmental Research and Public Health |
| Issue Number | 24 |
| Volume Number | 18 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-08 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Environmental Research and Public Health Peripheral Vascular Disease Cardiopulmonary Exercise Testing Heart Failure Peak Vo2 Treadmill Cycle Ergometer Exercise Test Mode |
| Content Type | Text |
| Resource Type | Article |
