NDLI: In-Vivo Antidiabetic Activity and In-Silico Mode of Action of LC/MS-MS Identified Flavonoids in Oleaster Leaves

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In-Vivo Antidiabetic Activity and In-Silico Mode of Action of LC/MS-MS Identified Flavonoids in Oleaster Leaves

Content Provider	MDPI
Author	Mechchate, Hamza Es-Safi, Imane Bourhia, Mohammed Kyrylchuk, Andrii Moussaoui, Abdelfattah El Conte, Raffaele Ullah, Riaz Ezzeldin, Essam Mostafa, Gamal A. Grafov, Andriy Bekkari, Hicham Bousta, Dalila
Copyright Year	2020
Description	Background: Olea europea L. subsp. europaea var. sylvestris (Mill) Lehr (Oleaster) is a wild endemic olive tree indigenous to the Mediterranean region. Olea europea leaves represent a natural reservoir of bioactive molecules that can be used for therapeutic purposes. Aim of the study: This work was conducted to study antidiabetic and antihyperglycemic activities of flavonoids from oleaster leaves using alloxan-induced diabetic mice. The mode of action of flavonoids against eight receptors that have a high impact on diabetes management and complication was also investigated using molecular docking. Results: During 28 days of mice treatment with doses 25 and 50 mg/kg b.w, the studied flavonoids managed a severe diabetic state (<450 mg/dL), exhibiting a spectacular antidiabetic and antihyperglycemic activity, and improved mice health status compared to diabetic control. The in-silico mode of action of oleaster flavonoids revealed the inhibition of protein tyrosine phosphatase 1B (PTP1B), Dipeptidyl-peptidase 4 (DPP4), α-Amylase (AAM), α-Glucosidase inhibition, Aldose reductase (AldR), Glycogen phosphorylase (GP), and the activation of free fatty acid receptor 1 (FFAR1). Conclusion: The findings obtained in the present work indicate that the flavonoids from the oleaster may constitute a safe multi-target remedy to treat diabetes.
Starting Page	5073
e-ISSN	14203049
DOI	10.3390/molecules25215073
Journal	Molecules
Issue Number	21
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-11-01
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Olea Europea L. Subsp. Europaea Var. Sylvestris (mill) Lehr Oleaster Diabetes Flavonoids Molecular Docking
Content Type	Text
Resource Type	Article

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