NDLI: Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)

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Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)

Content Provider	MDPI
Author	Lee, Chisong Kim, Jinkyung Um, Daniel Kim, Youseong Min, Hye Shin, Jiwoo Nam, Jee Kang, Geonwoo Jang, Mingyu Yang, Huisuk Jung, Hyungil
Copyright Year	2021
Description	Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems.
Starting Page	1058
e-ISSN	19994923
DOI	10.3390/pharmaceutics13071058
Journal	Pharmaceutics
Issue Number	7
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-07-10
Access Restriction	Open
Subject Keyword	Pharmaceutics Pharmacology and Pharmacy Poly(lactic-co-glycolic Acid) Dissolving Microneedle Sustained Release Melting Method Thermoplastic Characteristics Drug Delivery System
Content Type	Text
Resource Type	Article

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