NDLI: A Pilot Randomized Controlled Trial of Botulinum Toxin Treatment Combined with Robot-Assisted Therapy, Mirror Therapy, or Active Control Treatment in Patients with Spasticity Following Stroke

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A Pilot Randomized Controlled Trial of Botulinum Toxin Treatment Combined with Robot-Assisted Therapy, Mirror Therapy, or Active Control Treatment in Patients with Spasticity Following Stroke

Content Provider	MDPI
Author	Hung, Jen-Wen Yen, Chu-Ling Chang, Ku-Chou Chiang, Wei-Chi Chuang, I-Ching Pong, Ya-Ping Wu, Wen-Chi Wu, Ching-Yi
Copyright Year	2022
Description	Effects of the combined task-oriented trainings with botulinum toxin A (BoNT-A) injection on improving motor functions and reducing spasticity remains unclear. This study aims to investigate effects of 3 task-oriented trainings (robot-assisted therapy (RT), mirror therapy (MT), and active control treatment (AC)) in patients with stroke after BoNT-A injection. Thirty-seven patients with chronic spastic hemiplegic stroke were randomly assigned to receive RT, MT, or AC following BoNT-A injection over spastic upper extremity muscles. Each session of RT, MT, and AC was 75 min, 3 times weekly, for 8 weeks. Outcome measures were assessed at pretreatment, post-treatment, and 3-month follow-up, involving the Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS), Motor Activity Log (MAL), including amount of use (AOU) and quality of movement (QOM), and arm activity level. All 3 combined treatments improved FMA, MAS, and MAL. The AC induced a greater effect on QOM in MAL at the 3-month follow-up than RT or MT. All 3 combined trainings induced minimal effect on arm activity level. Our findings suggest that for patients with stroke who received BoNT-A injection over spastic UE muscles, the RT, MT, or AC UE training that followed was effective in improving motor functions, reducing spasticity, and enhancing daily function.
Starting Page	415
e-ISSN	20726651
DOI	10.3390/toxins14060415
Journal	Toxins
Issue Number	6
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-06-17
Access Restriction	Open
Subject Keyword	Toxins Stroke Rehabilitation Robot-assisted Training Mirror Therapy Conventional Rehabilitation Upper Extremity Motor Function
Content Type	Text
Resource Type	Article

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