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Incidence and Risk Factors of COVID-19 Vaccine Breakthrough Infections: A Prospective Cohort Study in Belgium
| Content Provider | MDPI |
|---|---|
| Author | Stouten, Veerle Hubin, Pierre Haarhuis, Freek van Loenhout, Joris A. F. Billuart, Matthieu Brondeel, Ruben Braeye, Toon Oyen, Herman Van Wyndham-Thomas, Chloé Catteau, Lucy |
| Copyright Year | 2022 |
| Description | The objective of this study was to investigate the incidence and risk factors associated with COVID-19 vaccine breakthrough infections. We included all persons ≥18 years that had been fully vaccinated against COVID-19 for ≥14 days, between 1 February 2021 and 5 December 2021, in Belgium. The incidence of breakthrough infections (laboratory confirmed SARS-CoV-2-infections) was determined. Factors associated with breakthrough infections were analyzed using COX proportional hazard models. Among 8,062,600 fully vaccinated adults, we identified 373,070 breakthrough infections with an incidence of 11.2 (95%CI 11.2–11.3)/100 person years. Vaccination with Ad26.COV2.S (HR1.54, 95%CI 1.52–1.56) or ChAdOx1 (HR1.68, 95%CI 1.66–1.69) was associated with a higher risk of a breakthrough infection compared to BNT162b2, while mRNA-1273 was associated with a lower risk (HR0.68, 95%CI 0.67–0.69). A prior COVID-19-infection was protective against a breakthrough infection (HR0.23, 95%CI 0.23–0.24), as was an mRNA booster (HR0.44, 95%CI 0.43–0.45). During a breakthrough infection, those who had a prior COVID-19 infection were less likely to have COVID-19 symptoms of almost all types than naïve persons. We identified risk factors associated with breakthrough infections, such as vaccination with adenoviral-vector vaccines, which could help inform future decisions on booster vaccination strategies. A prior COVID-19 infection lowered the risk of breakthrough infections and of having symptoms, highlighting the protective effect of hybrid immunity. |
| Starting Page | 802 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v14040802 |
| Journal | Viruses |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-13 |
| Access Restriction | Open |
| Subject Keyword | Viruses Infectious Diseases Vaccination Sars-cov-2 Breakthrough Infection Hybrid Immunity Viral Vector Vaccines Mrna Vaccines Symptoms Covid-19 Mrna Booster Vaccine |
| Content Type | Text |
| Resource Type | Article |
