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Antiviral Activity of Porcine IFN-λ3 and IFN-α against Porcine Rotavirus In Vitro
| Content Provider | MDPI |
|---|---|
| Author | Deng, Lishuang Yin, Yue Xu, Zhiwen Li, Fengqin Zhao, Jun Deng, Huidan Jian, Zhijie Lai, Siyuan Sun, Xiangang Zhu, Ling |
| Copyright Year | 2022 |
| Description | Interferons (IFNs) play a major role in the host’s antiviral innate immunity. In response to viral infection, IFNs bind their receptors and initiate a signaling cascade, leading to the accurate transcriptional regulation of hundreds of IFN-stimulated genes (ISGs). Porcine rotavirus (PoRV) belongs to genus Rotavirus of the Reoviridae family; the infection is a global epidemic disease and a major threat to the pig industry. In this study, we found that IFN-λ3 inhibited the replication of PoRV in both MA104 cells and IPEC-J2 cells, and this inhibition was dose-dependent. Furthermore, the antiviral activity of IFN-λ3 was more potent in IPEC-J2 cells than in MA104 cells. Further research showed that IFN-λ3 and IFN-α might inhibit PoRV infection by activating ISGs, i.e., MxA, OASL and ISG15, in IPEC-J2 cells. However, the co-treatment of IFN-λ3 and IFN-α did not enhance the antiviral activity. Our data demonstrated that IFN-λ3 had antiviral activity against PoRV and may serve as a useful antiviral candidate against PoRV, as well as other viruses in swine. |
| Starting Page | 4575 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27144575 |
| Journal | Molecules |
| Issue Number | 14 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-18 |
| Access Restriction | Open |
| Subject Keyword | Molecules Immunology Infectious Diseases Antiviral Activity Ifn-λ3 Ifn-α Porv |
| Content Type | Text |
| Resource Type | Article |
