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Cobaltabis(dicarbollide) $([o-COSAN]^{−}$) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma
| Content Provider | MDPI |
|---|---|
| Author | Amanda, Muñoz-Juan Clara, Viñas Nuez-Martinez, Miquel Pinto, Catarina I. G. Guerreiro, Joana F. Mendes, Filipa Marques, Fernanda Xavier, Jewel Ann Maria Laromaine, Anna Bitonto, Valeria Protti, Nicoletta Crich, Simonetta Geninatti Teixidor, Francesc |
| Copyright Year | 2021 |
| Description | Purpose: The aim of our study was to assess if the sodium salt of cobaltabis(dicarbollide) and its di-iodinated derivative (Na[o-COSAN] and $Na[8,8′-I_{2}$-o-COSAN]) could be promising agents for dual anti-cancer treatment (chemotherapy + BNCT) for GBM. Methods: The biological activities of the small molecules were evaluated in vitro with glioblastoma cells lines U87 and T98G in 2D and 3D cell models and in vivo in the small model animal Caenorhabditis elegans (C. elegans) at the L4-stage and using the eggs. Results: Our studies indicated that only spheroids from the U87 cell line have impaired growth after treatment with both compounds, suggesting an increased resistance from T98G spheroids, contrary to what was observed in the monolayer culture, which highlights the need to employ 3D models for future GBM studies. In vitro tests in U87 and T98G cells conclude that the amount of$ ^{10}$B inside the cells is enough for BNCT irradiation. BNCT becomes more effective on T98G after their incubation with $Na[8,8′-I_{2}$-o-COSAN], whereas no apparent cell-killing effect was observed for untreated cells. Conclusions: These small molecules, particularly [8,8′-I_{2}$-o-COSAN]^{−}$, are serious candidates for BNCT now that the facilities of accelerator-based neutron sources are more accessible, providing an alternative treatment for resistant glioblastoma. |
| Starting Page | 6367 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13246367 |
| Journal | Cancers |
| Issue Number | 24 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-19 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Boron Clusters Metallacarboranes Small Molecules Cosan Boron Neutron Capture Therapy (bnct) Glioblastoma 3d Cell Models in Vitro Bnct Effect C. Elegans |
| Content Type | Text |
| Resource Type | Article |
