NDLI: Influence of Galectin-3 on the Innate Immune Response during Experimental Cryptococcosis

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Influence of Galectin-3 on the Innate Immune Response during Experimental Cryptococcosis

Content Provider	MDPI
Author	Rezende, Caroline Brito, Patricia Silva, Thiago Da Pessoni, Andre Ramalho, Leandra Almeida, Fausto
Copyright Year	2021
Description	Cryptococcus neoformans, the causative agent of cryptococcosis, is the primary fungal pathogen that affects the immunocompromised individuals. Galectin-3 (Gal-3) is an animal lectin involved in both innate and adaptive immune responses. The present study aimed to evaluate the influence of Gal-3 on the C. neoformans infection. We performed histopathological and gene profile analysis of the innate antifungal immunity markers in the lungs, spleen, and brain of the wild-type (WT) and Gal-3 knockout (KO) mice during cryptococcosis. These findings suggest that Gal-3 absence does not cause significant histopathological alterations in the analyzed tissues. The expression profile of the genes related to innate antifungal immunity showed that the presence of cryptococcosis in the WT and Gal-3 KO animals, compared to their respective controls, promoted the upregulation of the pattern recognition receptor (PRR) responsive to mannose/chitin (mrc1) and a gene involved in inflammation (ccr5), as well as the downregulation of the genes related to signal transduction (card9, fos, ikbkb, jun) and PRRs (cd209a, colec12, nptx1). The absence of Gal-3, in fungal infection, a positively modulated gene involved in phagocytosis (sftpd) and negatively genes involved in signal transduction (syk and myd88), proinflammatory cytokines il-1β and il-12b and cd209a receptor. Therefore, our results suggest that Gal-3 may play an essential role in the development of antifungal immune responses against cryptococcosis.
Starting Page	492
e-ISSN	2309608X
DOI	10.3390/jof7060492
Journal	Journal of Fungi
Issue Number	6
Volume Number	7
Language	English
Publisher	MDPI
Publisher Date	2021-06-20
Access Restriction	Open
Subject Keyword	Journal of Fungi Mycology Cryptococcus Neoformans Galectin-3 (gal-3), Innate Antifungal Immunity
Content Type	Text
Resource Type	Article

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