NDLI: Molecular Targeted Positron Emission Tomography Imaging and Radionuclide Therapy of Pancreatic Ductal Adenocarcinoma

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Molecular Targeted Positron Emission Tomography Imaging and Radionuclide Therapy of Pancreatic Ductal Adenocarcinoma

Content Provider	MDPI
Author	Poels, Thomas T. Vuijk, Floris A. de Geus-Oei, Lioe-Fee Vahrmeijer, Alexander L. Oprea-Lager, Daniela E. Swijnenburg, Rutger-Jan
Copyright Year	2021
Description	Pancreatic ductal adenocarcinoma (PDAC) has an inauspicious prognosis, mainly due to difficulty in early detection of the disease by the current imaging modalities. The upcoming development of tumour-specific tracers provides an alternative solution for more accurate diagnostic imaging techniques for staging and therapy response monitoring. The future goal to strive for, in a patient with PDAC, should definitely be first to receive a diagnostic dose of an antibody labelled with a radionuclide and to subsequently receive a therapeutic dose of the same labelled antibody with curative intent. In the first part of this paper, we summarise the available evidence on tumour-targeted diagnostic tracers for molecular positron emission tomography (PET) imaging that have been tested in humans, together with their clinical indications. Tracers such as radiolabelled prostate-specific membrane antigen (PSMA)—in particular,$ ^{18}$F-labelled PSMA—already validated and successfully implemented in clinical practice for prostate cancer, also seem promising for PDAC. In the second part, we discuss the theranostic applications of these tumour-specific tracers. Although targeted radionuclide therapy is still in its infancy, lessons can already be learned from early publications focusing on dose fractioning and adding a radiosensitiser, such as gemcitabine.
Starting Page	6164
e-ISSN	20726694
DOI	10.3390/cancers13246164
Journal	Cancers
Issue Number	24
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-12-07
Access Restriction	Open
Subject Keyword	Cancers Urology and Nephrology Pancreatic Ductal Adenocarcinoma Positron Emission Tomography Radionuclide Tumour Tracer
Content Type	Text
Resource Type	Article

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