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Single-Molecule Surface-Enhanced Raman Spectroscopy
| Content Provider | MDPI |
|---|---|
| Author | Qiu, Yuxuan Kuang, Cuifang Liu, Xu Tang, Longhua |
| Copyright Year | 2022 |
| Description | Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has the potential to detect single molecules in a non-invasive, label-free manner with high-throughput. SM-SERS can detect chemical information of single molecules without statistical averaging and has wide application in chemical analysis, nanoelectronics, biochemical sensing, etc. Recently, a series of unprecedented advances have been realized in science and application by SM-SERS, which has attracted the interest of various fields. In this review, we first elucidate the key concepts of SM-SERS, including enhancement factor (EF), spectral fluctuation, and experimental evidence of single-molecule events. Next, we systematically discuss advanced implementations of SM-SERS, including substrates with ultra-high EF and reproducibility, strategies to improve the probability of molecules being localized in hotspots, and nonmetallic and hybrid substrates. Then, several examples for the application of SM-SERS are proposed, including catalysis, nanoelectronics, and sensing. Finally, we summarize the challenges and future of SM-SERS. We hope this literature review will inspire the interest of researchers in more fields. |
| Starting Page | 4889 |
| e-ISSN | 14248220 |
| DOI | 10.3390/s22134889 |
| Journal | Sensors |
| Issue Number | 13 |
| Volume Number | 22 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-29 |
| Access Restriction | Open |
| Subject Keyword | Sensors Spectroscopy Surface-enhanced Raman Spectroscopy Single-molecule Detection Surface Plasmon Resonance Nanoparticle |
| Content Type | Text |
| Resource Type | Article |
