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Alternative CAR Therapies: Recent Approaches in Engineering Chimeric Antigen Receptor Immune Cells to Combat Cancer
| Content Provider | MDPI |
|---|---|
| Author | Moreno, Carlos Haynie, Christopher Johnson, Abigail Weber, K. Scott |
| Copyright Year | 2022 |
| Description | For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of researchers seeking to find novel immunotherapies to treat cancer. CARs were first designed to work with T cells, and the first CAR T cell therapy was approved to treat B cell lymphoma in 2017. Recent advancements in CAR technology have led to the development of modified CARs, including multi-specific CARs and logic gated CARs. Other immune cell types, including natural killer (NK) cells and macrophages, have also been engineered to express CARs to treat cancer. Additionally, CAR technology has been adapted in novel approaches to treating autoimmune disease and other conditions and diseases. In this article, we review these recent advancements in alternative CAR therapies and design, as well as their mechanisms of action, challenges in application, and potential future directions. |
| Starting Page | 1493 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10071493 |
| Journal | Biomedicines |
| Issue Number | 7 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-24 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Oncology T Cell Chimeric Antigen Receptor Car Nk Cell Macrophage Autoimmune Cancer Immunotherapy Autoreactive B Cell Cytotoxicity |
| Content Type | Text |
| Resource Type | Article |
