NDLI: Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics

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Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics

Content Provider	MDPI
Author	Jimenez-Luna, Cristina Martin-Blazquez, Ariadna Dieguez-Castillo, Carmelo Diaz, Caridad Martin-Ruiz, Jose Genilloud, Olga Vicente, Francisca Palacio, Jose Del Prados, Jose Caba, Octavio
Copyright Year	2020
Description	Pancreatogenic diabetes mellitus (T3cDM) is a highly frequent complication of pancreatic disease, especially chronic pancreatitis, and it is often misdiagnosed as type 2 diabetes mellitus (T2DM). A correct diagnosis allows the appropriate treatment of these patients, improving their quality of life, and various technologies have been employed over recent years to search for specific biomarkers of each disease. The main aim of this metabolomic project was to find differential metabolites between T3cDM and T2DM. Reverse-phase liquid chromatography coupled to high-resolution mass spectrometry was performed in serum samples from patients with T3cDM and T2DM. Multivariate Principal Component and Partial Least Squares-Discriminant analyses were employed to evaluate between-group variations. Univariate and multivariate analyses were used to identify potential candidates and the area under the receiver-operating characteristic (ROC) curve was calculated to evaluate their diagnostic value. A panel of five differential metabolites obtained an area under the ROC curve of 0.946. In this study, we demonstrate the usefulness of untargeted metabolomics for the differential diagnosis between T3cDM and T2DM and propose a panel of five metabolites that appear altered in the comparison between patients with these diseases.
Starting Page	423
e-ISSN	22181989
DOI	10.3390/metabo10110423
Journal	Metabolites
Issue Number	11
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-10-22
Access Restriction	Open
Subject Keyword	Metabolites Biochemical Research Metabolomics Untargeted Lc-hrms Diagnosis Pancreatogenic Diabetes Mellitus Type 2 Diabetes Mellitus Chronic Pancreatitis Biomarker
Content Type	Text
Resource Type	Article

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