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Prebiotic Galacto-Oligosaccharides Impact Stool Frequency and Fecal Microbiota in Self-Reported Constipated Adults: A Randomized Clinical Trial
| Content Provider | MDPI |
|---|---|
| Author | Schoemaker, Marieke H. Hageman, Jeske H. J. Haaf, Dominique Ten Hartog, Anita Scholtens, Petra A. M. J. Boekhorst, Jos Nauta, Arjen Bos, Rolf |
| Copyright Year | 2022 |
| Description | Constipation is a major issue for 10–20% of the global population. In a double-blind randomized placebo-controlled clinical trial, we aimed to determine a dose-response effect of galacto-oligosaccharides (GOS) on stool characteristics and fecal microbiota in 132 adults with self-reported constipation according to Rome IV criteria (including less than three bowel movements per week). Subjects (94% females, aged: 18–59 years) received either 11 g or 5.5 g of $Biotis^{TM}$ GOS, or a control product, once daily for three weeks. Validated questionnaires were conducted weekly to study primarily stool frequency and secondary stool consistency. At base- and endline, stool samples were taken to study fecal microbiota. A trend towards an increased stool frequency was observed after the intervention with 11 g of GOS compared to control. While during screening everybody was considered constipated, not all subjects (n = 78) had less than three bowel movements per week at baseline. In total, 11 g of GOS increased stool frequency compared to control in subjects with a low stool frequency at baseline (≤3 bowel movements per week) and in self-reported constipated adults 35 years of age or older. A clear dose-response of GOS was seen on fecal Bifidobacterium, and 11 g of GOS significantly increased Anaerostipes hadrus. In conclusion, GOS seems to be a solution to benefit adults with a low stool frequency and middle-aged adults with self-reported constipation. |
| Starting Page | 309 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu14020309 |
| Journal | Nutrients |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-12 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Galacto-oligosaccharides Stool Frequency Stool Consistency Stool Characteristics Constipation Microbiota |
| Content Type | Text |
| Resource Type | Article |
