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Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration
| Content Provider | MDPI |
|---|---|
| Author | Enrique, Rodríguez-Castellón Maia, Marcella Soares, Ana Caetano, Matheus Andrade, Fábia Vieira, Rodrigo |
| Copyright Year | 2021 |
| Description | Cellulose acetate (CA)/strontium phosphate (SrP) hybrid coating has been proposed as an effective strategy to build up novel bone-like structures for bone healing since CA is soluble in most organic solvents. Strontium $(Sr^{2+}$) has been reported as a potential agent to treat degenerative bone diseases due to its osteopromotive and antibacterial effects. Herein, bioactive hybrid composite SrP-based coatings (CASrP) were successfully produced for the first time. CASrP was synthesized via a modified biomimetic method (for 7—CA7dSrP, and 14 days—CA14dSrP), in which the metal ion $Sr^{2+}$ was used in place of $Ca^{2+}$ in the simulated body fluid. Energy-dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR) analysis confirmed the SrP incorporation chemically in the CASrP samples. Atomic absorption spectroscopy (AAS) supported EDX data, showing $Sr^{2+}$ adsorption into CA, and its significant increase with the augmentation of time of treatment (ca. 92%—CA7dSrP and 96%—CA14dSrP). An increment in coating porosity and the formation of SrP crystals were evidenced by scanning electron microscopy (SEM) images. X-ray diffraction (XRD) evidenced a greater crystallinity than CA membranes and a destabilization of CA14dSrP structure compared to CA7dSrP. The composites were extremely biocompatible for fibroblast and osteoblast cells. Cell viability (%) was higher either for CA7dSrP (48 h: ca. 92% and 115%) and CA14dSrP (48 h: ca. 88% and 107%) compared to CA (48 h: ca. 70% and 51%) due to SrP formation and $Sr^{2+}$ presence in its optimal dose in the culture media (4.6–9 $mg·L^{−1}$). In conclusion, the findings elucidated here evidence the remarkable potential of CA7dSrP and CA14dSrP as bioactive coatings on the development of implant devices for inducing bone regeneration. |
| Starting Page | 908 |
| e-ISSN | 20796412 |
| DOI | 10.3390/coatings11080908 |
| Journal | Coatings |
| Issue Number | 8 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-29 |
| Access Restriction | Open |
| Subject Keyword | Coatings Coatings and Films Bone-implant Interface Adverse Effects Biopolymers Biomineralization Hydroxyapatite Derivatives |
| Content Type | Text |
| Resource Type | Article |
