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Regioselective Mercury(I)/Palladium(II)-Catalyzed Single-Step Approach for the Synthesis of Imines and 2-Substituted Indoles
| Content Provider | MDPI |
|---|---|
| Author | Rsuini, Gutiérrez Mayra, Hernández-Montes Mendieta-Moctezuma, Aarón Delgado, Francisco Tamariz, Joaquín |
| Copyright Year | 2021 |
| Description | An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cyclization of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H activation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives. |
| Starting Page | 4092 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26134092 |
| Journal | Molecules |
| Issue Number | 13 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-05 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Mercury(i)-catalyzed Alkyne Hydroamination Imines Pd-catalyzed Oxidative Cyclization One-pot Indole Synthesis |
| Content Type | Text |
| Resource Type | Article |
