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Performance Enhancement of SPR Biosensor Using $Graphene–MoS_{2}$ Hybrid Structure
| Content Provider | MDPI |
|---|---|
| Author | Cai, Haoyuan Wang, Mengwei Wu, Zhuo Hui Liu, Jing Wang, Xiaoping |
| Copyright Year | 2022 |
| Description | We investigate a high-sensitivity surface plasmon resonance (SPR) biosensor consisting of a Au layer, four-layer $MoS_{2}$, and monolayer graphene. The numerical simulations, by the transfer matrix method (TMM), demonstrate the sensor has a maximum sensitivity of 282°/RIU, which is approximately 2 times greater than the conventional Au-based SPR sensor. The finite difference time domain (FDTD) indicates that the presence of $MoS_{2}$ film generates a strong surface electric field and enhances the sensitivity of the proposed SPR sensor. In addition, the influence of the number of $MoS_{2}$ layers on the sensitivity of the proposed sensor is investigated by simulations and experiments. In the experiment, $MoS_{2}$ and graphene films are transferred on the Au-based substrate by the PMMA-based wet transfer method, and the fabricated samples are characterized by Raman spectroscopy. Furthermore, the fabricated sensors with the Kretschmann configuration are used to detect okadaic acid (OA). The okadaic acid–bovine serum albumin bioconjugate (OA-BSA) is immobilized on the graphene layer of the sensors to develop a competitive inhibition immunoassay. The results show that the sensor has a very low limit of detection (LOD) of 1.18 ng/mL for OA, which is about 22.6 times lower than that of a conventional Au biosensor. We believe that such a high-sensitivity SPR biosensor has potential applications for clinical diagnosis and immunoassays. |
| Starting Page | 2219 |
| e-ISSN | 20794991 |
| DOI | 10.3390/nano12132219 |
| Journal | Nanomaterials |
| Issue Number | 13 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-28 |
| Access Restriction | Open |
| Subject Keyword | Nanomaterials Analytical Chemistry Biosensor Mos2 Graphene Spr Sensor High Sensitivity |
| Content Type | Text |
| Resource Type | Article |
