NDLI: The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

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The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

Content Provider	MDPI
Author	Liberini, Virginia Huellner, Martin Grimaldi, Serena Finessi, Monica Thuillier, Philippe Muni, Alfredo Pellerito, Riccardo Papotti, Mauro Piovesan, Alessandro Arvat, Emanuela Deandreis, Désirée
Copyright Year	2020
Description	The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT response assessment is challenging and no consensus on methods and timing has yet been reached among experts in the field. This issue is owed to the suboptimal sensitivity and specificity of clinical biomarkers, limitations of morphological response criteria in slowly growing tumors and necrotic changes after therapy, a lack of standardized parameters and timing of functional imaging and the heterogeneity of PRRT protocols in the literature. The aim of this article is to review the most relevant current approaches for PRRT efficacy prediction and response assessment criteria in order to provide an overview of suitable tools for safe and efficacious PRRT.
Starting Page	1083
e-ISSN	20754418
DOI	10.3390/diagnostics10121083
Journal	Diagnostics
Issue Number	12
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-12-12
Access Restriction	Open
Subject Keyword	Diagnostics Endocrinology and Metabolism Peptide Receptor Radionuclide Therapy Prrt 68ga-labeled Somatostatin Analogue 18f-fdg Response Assessment Recist Swog Who Neuroendocrine Tumors Net
Content Type	Text
Resource Type	Article

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