NDLI: Novel Coumarin-Thiadiazole Hybrids and Their Cu(II) and Zn(II) Complexes as Potential Antimicrobial Agents and Acetylcholinesterase Inhibitors

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Novel Coumarin-Thiadiazole Hybrids and Their Cu(II) and Zn(II) Complexes as Potential Antimicrobial Agents and Acetylcholinesterase Inhibitors

Content Provider	MDPI
Author	Daniel, Kamiński Anna, Miłoś Lidia, Ślusarczyk Karcz, Dariusz Starzak, Karolina Ciszkowicz, Ewa Lecka-Szlachta, Katarzyna Creaven, Bernadette Jenkins, Hollie Radomski, Piotr Matwijczuk, Arkadiusz
Copyright Year	2021
Description	A series of coumarin-thiadiazole hybrids and their corresponding Cu(II) and Zn(II) complexes were synthesized and characterized with the use of spectroscopic techniques. The results obtained indicate that all the coumarin-thiadiazole hybrids act as bidentate chelators of Cu(II) and Zn(II) ions. The complexes isolated differ in their ligand:metal ratio depending on the central metal. In most cases, the Zn(II) complexes are characteristic of a 1:1 ligand:metal ratio, while in the Cu(II) complexes the ligand:metal ratio is 2:1. All compounds were tested as potential antibacterial agents against Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains demonstrating activities notably lower than commercially available antibiotics. The more promising results were obtained from the assessment of antineurodegenerative potency as all compounds showed moderate acetylcholinesterase (AChE) inhibition activity
Starting Page	9709
e-ISSN	14220067
DOI	10.3390/ijms22189709
Journal	International Journal of Molecular Sciences
Issue Number	18
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-09-08
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Coumarin Thiadiazole Hybrids Complexes Antimicrobial Antibacterial Activity Acetylcholinesterase Inhibitors Neurodegeneration
Content Type	Text
Resource Type	Article

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