NDLI: LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling

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LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling

Content Provider	MDPI
Author	Lu, Qingchun Guo, Qian Xin, Mingyang Lim, Casey Gamero, Ana M. Gerhard, Glenn S. Yang, Ling
Copyright Year	2021
Description	Long non-coding RNA (lncRNA) TP53 target 1 (TP53TG1) was discovered as a TP53 target gene. TP53TG1 has been reported as having dual roles by exerting tumor-suppressive and oncogenic activities that vary depending on the cancer type. Yet, the role of TP53TG1 in hepatocellular carcinoma (HCC) is not fully understood. In this study, we performed both gain- and loss-of-function studies to determine the biological role of TP53TG1 in HCC. We found that the knockdown of TP53 in HCC cells caused the upregulation of TP53TG1. Furthermore, we found that the knockdown of TP53TG1 not only suppressed HCC cell proliferation and migration, but also reduced intrinsic ERK signaling. In contrast, the overexpression of TP53TG1 increased ERK activation and enhanced HCC proliferation. In conclusion, our study reveals an oncogenic role of TP53TG1 in HCC, which provides a novel insight into the cell-type-specific function of TP53TG1 in HCC.
Starting Page	52
e-ISSN	2311553X
DOI	10.3390/ncrna7030052
Journal	Non-Coding RNA
Issue Number	3
Volume Number	7
Language	English
Publisher	MDPI
Publisher Date	2021-08-28
Access Restriction	Open
Subject Keyword	Non-Coding RNA Non-coding Rna Oncology Long Non-coding Rna Tp53tg1 Hepatocellular Carcinoma Erk Pathway Oncogene
Content Type	Text
Resource Type	Article

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