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Enantioselective Chromatographic Separation and Lipase Catalyzed Asymmetric Resolution of Biologically Important Chiral Amines
| Content Provider | MDPI |
|---|---|
| Author | El-Behairy, Mohammed Farrag Hassan, Rasha M. Sundby, Eirik |
| Copyright Year | 2021 |
| Description | Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or methoxyacetamides RS-(1b–4b) in enantiopure/enriched form was investigated. Compounds S-1, S-2, R-1b, R-1a, andR-2b were prepared in enantiopure form (ee > 99%) while compounds S-4, R-2a, and R-4a were achieved in ee 9%, 80%, and 76%, respectively. Many baselines enantioselective HPLC separations of amines 1–4, their cyanoacetamides (1a–4a), and methoxyacetamides (1b–4b) were achieved by utilizing diverse mobile-phase compositions and two cellulose-based CSPs $(ODH^{®}$ and $LUX-3^{®}$ columns). Such enantioselective HPLC separations were used to monitor the lipase-catalyzed kinetic resolution of amines RS-(1–4). |
| Starting Page | 165 |
| e-ISSN | 22978739 |
| DOI | 10.3390/separations8100165 |
| Journal | Separations |
| Issue Number | 10 |
| Volume Number | 8 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-30 |
| Access Restriction | Open |
| Subject Keyword | Separations Analytical Chemistry Cyanoacetamide Chiral Amines Enantioselective Chromatography Lipase Kinetic Resolution |
| Content Type | Text |
| Resource Type | Article |
