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Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings
| Content Provider | MDPI |
|---|---|
| Author | Do, Richard Kinh Reyngold, Marsha Paudyal, Ramesh Oh, Jung Hun Konar, Amaresha Shridhar LoCastro, Eve Goodman, Karyn A. Shukla-Dave, Amita |
| Copyright Year | 2020 |
| Abstract | We aimed to assess longitudinal changes in quantitative imaging metric values obtained from diffusion-weighted (DW-) and dynamic contrast-enhanced magnetic resonance imaging (DCE)-MRI at pre-treatment (TX[0]), immediately after the first fraction of stereotactic body radiotherapy (D1-TX[1]), and 6 weeks post-TX (Post-TX[2]) in patients with pancreatic ductal adenocarcinoma. Ten enrolled patients (n = 10) underwent DW- and DCE-MRI examinations on a 3.0 T scanner. The apparent diffusion coefficient, ADC (mm2/s), was derived from DW imaging data using a monoexponential model. The tissue relaxation rate, R1t, time-course data were fitted with a shutter-speed model, which provides estimates of the volume transfer constant, Ktrans (min−1), extravascular extracellular volume fraction, ve, and mean lifetime of intracellular water protons, τi (seconds). Wilcoxon rank-sum test compared the mean values, standard deviation, skewness, kurtosis, and relative percentage (r, %) changes (Δ) in ADC, Ktrans, ve, and τi values between the magnetic resonance examinations. rADCΔ2–0 values were significantly greater than rADCΔ1-0 values (P = .009). rKtransΔ2–0 values were significantly lower than rKtrans Δ1-0 values (P = .048). rveΔ2-1 and rveΔ2-0 values were significantly different (P = .016). rτiΔ2-1 values were significantly lower than rτiΔ2-0 values (P = .008). For group comparison, the pre-TX mean and kurtosis of ADC (P = .18 and P = .14), skewness and kurtosis of Ktrans values (P = .14 for both) showed a leaning toward significant difference between patients who experienced local control (n = 2) and failed early (n = 4). DW- and DCE-MRI-derived quantitative metrics could be useful biomarkers to evaluate longitudinal changes to stereotactic body radiotherapy in patients with pancreatic ductal adenocarcinoma. |
| Ending Page | 271 |
| Page Count | 11 |
| Starting Page | 261 |
| e-ISSN | 2379139X |
| DOI | 10.18383/j.tom.2020.00015 |
| Journal | Tomography |
| Issue Number | 2 |
| Volume Number | 6 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-06-01 |
| Access Restriction | Open |
| Subject Keyword | Tomography Radiology, Nuclear Medicine and Imaging Pre Magnetic Resonance Dce Mri Skewness Longitudinal Changes Dw and Dce Mri Derived |
| Content Type | Text |
| Resource Type | Article |
