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Magnetic Hyperthermia on $γ-Fe_{2}O_{3}@SiO_{2}$ Core-Shell Nanoparticles for mi-RNA 122 Detection
| Content Provider | MDPI |
|---|---|
| Author | Horny, Marie-Charlotte Gamby, Jean Dupuis, Vincent Siaugue, Jean-Michel |
| Copyright Year | 2021 |
| Description | Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe2O3 cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow the grafting at their surface of a significant number of oligonucleotides but are also shown to be as efficient, by local heating, as 95 °C global heating when submitted to an alternative magnetic field, while keeping the solution at 28 °C, crucial for biological media and energy efficiency. Moreover, a slight modification of the silica coating process revealed an increased heating power, well adapted for the release of small oligonucleotides such as microRNA. |
| Starting Page | 149 |
| e-ISSN | 20794991 |
| DOI | 10.3390/nano11010149 |
| Journal | Nanomaterials |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-09 |
| Access Restriction | Open |
| Subject Keyword | Nanomaterials Nucleic Acids Magnetic Hyperthermia Core-shell Nanoparticles Early Diagnosis |
| Content Type | Text |
| Resource Type | Article |
