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Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy
| Content Provider | MDPI |
|---|---|
| Author | Pellegrino, Marsha Bufalo, Francesca Del Angelis, Biagio De Quintarelli, Concetta Caruana, Ignazio Billy, Emmanuel De |
| Copyright Year | 2020 |
| Description | The adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metabolic fitness needs to be optimal to reach the tumor and execute their cytolytic function in an environment often hostile. It is now well established that both tumor and T cell metabolisms play critical roles in controlling the immune response by conditioning the tumor microenvironment and the fate and activity of the T cells. In this review, after a brief description of the tumoral and T cell metabolic reprogramming, we summarize the latest advances and new strategies that have been developed to improve the metabolic fitness and efficacy of CAR T-cell products. |
| Starting Page | 14 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells10010014 |
| Journal | Cells |
| Issue Number | 1 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-12-24 |
| Access Restriction | Open |
| Subject Keyword | Cells Cell Tissue Engineering Cancer Metabolic Reprogramming Combined Therapy Chimeric Antigen Receptor T Cells Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
