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Thyroid Biokinetics for Radioactive I-131 in Twelve Thyroid Cancer Patients via the Refined Nine-Compartmental Model
| Content Provider | MDPI |
|---|---|
| Author | Pan, Lung-Fa Chiang, Chao-Yu Huang, Chao-Chun Kao, Hua-Tsan Chen, Chih-Feng Peng, Bing-Ru Pan, Lung-Kwang |
| Copyright Year | 2022 |
| Description | The thyroid biokinetic model of radioactive I-131 was re-evaluated using a refined nine-compartmental model and applied to twelve thyroid cancer patients. In contrast to the simplified four-compartmental model regulated by the ICRP-56 report, the revised model included nine compartments specified in the ICRP-128 report, namely, oral, stomach, body fluid, thyroid, whole body, liver, kidney, bladder, and remainder (i.e., the whole body minus kidney and bladder). A self-developed program run in MATLAB was designed to solve the nine first-order simultaneous linear differential equations. The model was realized in standard and simplified versions. The latter neglected two feedback paths (body fluid to oral, $i_{31}$, and kidney to the whole body, $i_{87}$) to reduce computations. Accordingly, the biological half-lives for the major compartments (thyroid and body fluid + whole body) were 36.00 ± 15.01, 15.04 ± 5.63, 34.33 ± 15.42, and 14.83 ± 5.91 of standard and simplified version. The correlations between theoretical and empirical data for each patient were quantified by the dimensionless AT (agreement) index and, the $AT_{tot}$ index integrated each individual AT of a specific organ of one patient. Since small AT values indicated a closer correlation, the obtained range of $AT_{tot}$ (0.048 ± 0.019) proved the standard model’s reliability and high accuracy, while the simplified one yielded slightly higher $AT_{tot}$ (0.058 ± 0.023). The detailed outcomes among various compartments of twelve patients were calculated and compared with other researchers’ work. The correlation results on radioactive I-131 evolution in thyroid cancer patients’ bodies are instrumental in viewpoint of radioactive protection of patients and radiological personnel. |
| Starting Page | 5538 |
| e-ISSN | 20763417 |
| DOI | 10.3390/app12115538 |
| Journal | Applied Sciences |
| Issue Number | 11 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-05-30 |
| Access Restriction | Open |
| Subject Keyword | Applied Sciences Endocrinology and Metabolism Biokinetic Model I-131 Matlab Thyroid Nine-compartmental Model |
| Content Type | Text |
| Resource Type | Article |
