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The Potential of Immune Modulation in Therapeutic HIV-1 Vaccination
| Content Provider | MDPI |
|---|---|
| Author | Yves, Lévy Seddiki, Nabila Picard, Florence Dupaty, Léa Godot, Véronique |
| Copyright Year | 2020 |
| Description | We discuss here some of the key immunological elements that are at the crossroads and need to be combined to develop a potent therapeutic HIV-1 vaccine. Therapeutic vaccines have been commonly used to enhance and/or recall pre-existing HIV-1-specific cell-mediated immune responses aiming to suppress virus replication. The current success of immune checkpoint blockers in cancer therapy renders them very attractive to use in HIV-1 infected individuals with the objective to preserve the function of HIV-1-specific T cells from exhaustion and presumably target the persistent cellular reservoir. The major latest advances in our understanding of the mechanisms responsible for virus reactivation during therapy-suppressed individuals provide the scientific basis for future combinatorial therapeutic vaccine development. |
| Starting Page | 419 |
| e-ISSN | 2076393X |
| DOI | 10.3390/vaccines8030419 |
| Journal | Vaccines |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-07-27 |
| Access Restriction | Open |
| Subject Keyword | Vaccines Immunology Cytokines Immune Checkpoint Blockers Combinatorial Intervention Hiv-1 Therapeutic Vaccine |
| Content Type | Text |
| Resource Type | Article |
