NDLI: Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

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Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

Content Provider	MDPI
Author	Mezentsev, Alexandre Bezsonov, Evgeny Kashirskikh, Dmitry Baig, Mirza Eid, Ali Orekhov, Alexander
Copyright Year	2021
Description	This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contributing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis.
Starting Page	600
e-ISSN	22279059
DOI	10.3390/biomedicines9060600
Journal	Biomedicines
Issue Number	6
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-05-25
Access Restriction	Open
Subject Keyword	Biomedicines Pathology Atherogenesis Desialylation Ldl Hdl Apolipoproteins Sialidase Trans-sialidase Anti-ldl Antibodies Animal Models of Atherosclerosis Diagnostics of Atherosclerosis Treatment Options for Atherosclerosis
Content Type	Text
Resource Type	Article

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