NDLI: Study on Synergistic Antioxidant Effect of Typical Functional Components of Hydroethanolic Leaf Extract from Ginkgo Biloba In Vitro

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Study on Synergistic Antioxidant Effect of Typical Functional Components of Hydroethanolic Leaf Extract from Ginkgo Biloba In Vitro

Content Provider	MDPI
Author	Zhang, Lihu Zhu, Chunyi Liu, Xiaoqing Su, Erzheng Cao, Fuliang Zhao, Linguo
Copyright Year	2022
Description	The predicted anti-oxidation is related to apoptosis, proliferation, lipid metabolism, cell differentiation, and immune response. There are some differences in the antioxidant capacity of the four typical components of ginkgo biloba extract (EGb) including ginkgo flavone (GF), ginkgolide (G), procyanidins (OPC), and organic acids (OA), and any two members of them can exhibit apparent synergistic effects. The order of DPPH scavenging ability was: OPC > GF > OA > G. The scavenging ability of procyanidins was close to that of VC; the scavenging capacity of ABTS was GF > OPC > OA > G. The GF:OPC (1:9) showed the best synergism in scavenging DPPH and ABTS radicals. The 193 kinds of small molecules reported in EGb were obtained by analyzing the properties of EGb. In order to construct a corresponding biological activity target set, molecular docking and the network pharmacology method were employed to build the molecular action mechanism network of a compound target, and the main biological functions and signaling pathways involved with their antioxidant activities were predicted. The results displayed that the top ten compounds which belonged to the two broad categories, ginkgo flavonoids and proanthocyanidins, could interact closely with several important target proteins (CASP3, SOD2, MAPK1, HSPA4, and NQO1). This would be expected to lay a theoretical foundation for the deep development of Ginkgo biloba extract.
Starting Page	439
e-ISSN	14203049
DOI	10.3390/molecules27020439
Journal	Molecules
Issue Number	2
Volume Number	27
Language	English
Publisher	MDPI
Publisher Date	2022-01-10
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Toxicology Ginkgo Biloba Extract (egb) Synergism Antioxidation Ginkgo Flavone Ginkgolide
Content Type	Text
Resource Type	Article

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