Loading...
Please wait, while we are loading the content...
Similar Documents
Decrease of Pneumococcal Community-Acquired Pneumonia Hospitalization and Associated Complications in Children after the Implementation of the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) in Taiwan
| Content Provider | MDPI |
|---|---|
| Author | Shen, Ching-Fen Chen, Ju-Ling Su, Chien-Chou Lin, Wen-Liang Hsieh, Min-Ling Liu, Ching-Chun Cheng, Ching-Lan |
| Copyright Year | 2021 |
| Description | The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on overall community-acquired pneumonia (CAP) and disease severity still needs thorough evaluation. In this study, we retrieve both pneumococcal CAP (P-CAP) and unspecific CAP (U-CAP) inpatient data from the Taiwan National Health Insurance Database (NHID) between 2005 and 2016. The interrupted time-series (ITS) analysis was performed to compare the incidence trend before and after the implementation of PCV13. After PCV13 implementation, there is a significant decreasing trend of P-CAP hospitalization, especially in children <1 year, 2–5 years, adults aged 19–65 years, 66 years, or older (all p value < 0.05). This corresponds to a 59% reduction in children <1 year, 47% in children aged 2–5 years, 39% in adult aged 19–65 years, and 41% in elderly aged 66 years or older. The intensive care rate (6.8% to 3.9%), severe pneumonia cases (21.7 to 14.5 episodes per 100,000 children–years), and the need for invasive procedures (4.3% to 2.0%) decreased in children aged 2–5 years (p value < 0.0001) with P-CAP. This PCV13 implementation program in Taiwan not only reduced the incidence of P-CAP, but also attenuated disease severity, especially in children aged 2–5 years. |
| Starting Page | 1043 |
| e-ISSN | 2076393X |
| DOI | 10.3390/vaccines9091043 |
| Journal | Vaccines |
| Issue Number | 9 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-18 |
| Access Restriction | Open |
| Subject Keyword | Vaccines Infectious Diseases Tropical Medicine Community-acquired Pneumonia Pneumococcal Pneumonia Bacterial Pneumonia 13-valent Pneumococcal Conjugate Vaccine |
| Content Type | Text |
| Resource Type | Article |
