NDLI: Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer

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Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer

Content Provider	MDPI
Author	Kim, Dohun Kim, Yujin Lee, Bo Bin Kim, Dongho Lee, Ok-Jun Jeong, Pildu Kim, Wun-Jae Cho, Eun Yoon Han, Joungho Shim, Young Mog Kim, Duk-Hwan
Copyright Year	2020
Description	This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immunohistochemistry in formalin-fixed paraffin-embedded tissues from 425 early stage NSCLC patients. Reduced NME1 expression was found in 39% of samples. The median duration of follow-up was 56 months, and recurrence was found in 186 (44%) of 425 patients. The negative effect of reduced NME1 expression on RFS was worsened by cisplatin-based adjuvant chemotherapy (adjusted hazard ratio = 3.26, 95% CI = 1.16–9.17, p = 0.03). β-catenin overexpression exacerbated the effect of reduced NME1 expression on RFS and the negative effect was greater when receiving cisplatin-based adjuvant chemotherapy: among patients treated with cisplatin-based adjuvant chemotherapy, hazard ratios of patients with reduced NME1 expression increased from 5.59 (95% confidence interval (CI) = 0.62–50.91, p = 0.13) to 15.52 (95% CI = 2.94–82.38, p = 0.001) by β-catenin overexpression, after adjusting for confounding factors. In conclusion, the present study suggests that cisplatin-based adjuvant chemotherapy needs to be carefully applied to early stage NSCLC patients with overexpressed β-catenin in combination with reduced NME1 expression.
Starting Page	3067
e-ISSN	20770383
DOI	10.3390/jcm9103067
Journal	Journal of clinical medicine
Issue Number	10
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2020-09-23
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Adjuvant Chemotherapy Β-catenin Lung Neoplasms Nucleotide-diphosphate Kinase Recurrence
Content Type	Text
Resource Type	Article

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