Loading...
Please wait, while we are loading the content...
Similar Documents
Circulating Exhausted $PD-1^{+}CD39^{+}$ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
| Content Provider | MDPI |
|---|---|
| Author | Fran, çoise Lauzéral-Vizcaino Virginie, Féliu Camille-Charlotte, Balança Martinez-Gomez, Carlos Michelas, Marie Scarlata, Clara-Maria Salvioni, Anna Gomez-Roca, Carlos Sarradin, Victor Dupret-Bories, Agnès Ferron, Gwénaël Sarini, Jérôme Devaud, Christel Delord, Jean-Pierre Martinez, Alejandra Ayyoub, Maha |
| Copyright Year | 2022 |
| Description | Tumor-infiltrating exhausted $PD-1^{hi}CD39^{+}$ tumor-antigen (Ag)-specific CD4 T cells contribute to the response to immune checkpoint blockade (ICB), but their circulating counterparts, which could represent accessible biomarkers, have not been assessed. Here, we analyzed circulating $PD-1^{+}CD39^{+}$ CD4 T cells and show that this population was present at higher proportions in cancer patients than in healthy individuals and was enriched in activated $HLA-DR^{+}$ and $ICOS^{+}$ and proliferating $KI67^{+}$ cells, indicative of their involvement in ongoing immune responses. Among memory CD4 T cells, this population contained the lowest proportions of cells producing effector cytokines, suggesting they were exhausted. In patients with HPV-induced malignancies, the $PD-1^{+}CD39^{+}$ population contained high proportions of HPV Ag-specific T cells. In patients treated by ICB for HPV-induced tumors, the proportion of circulating $PD-1^{+}CD39^{+}$ CD4 T cells was predictive of the clinical response. Our results identify CD39 expression as a surrogate marker of circulating helper tumor-Ag-specific CD4 T cells. |
| Starting Page | 3679 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers14153679 |
| Journal | Cancers |
| Issue Number | 15 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-28 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Cd4 T-cell Response Tumor Antigens Cancer Immunotherapy Circulating Biomarkers |
| Content Type | Text |
| Resource Type | Article |
