Loading...
Please wait, while we are loading the content...
Similar Documents
Probiotics-Supplemented Low-Protein Diet for Microbiota Modulation in Patients with Advanced Chronic Kidney Disease (ProLowCKD): Results from a Placebo-Controlled Randomized Trial
| Content Provider | MDPI |
|---|---|
| Author | Mauri, Andreana De Carrera, Deborah Bagnati, Marco Rolla, Roberta Vidali, Matteo Chiarinotti, Doriana Pane, Marco Amoruso, Angela Piano, Mario Del |
| Copyright Year | 2022 |
| Description | The probiotics-supplemented low-protein diet in chronic kidney disease (ProLowCKD) was a single-centre, double-blind, placebo-controlled, randomised trial that was conducted to investigate whether the association between a low protein diet (LPD) and a new formulation of probiotics (Bifidobacterium longum and Lactobacillus reuteri) was effective at reducing traditional uremic, microbiota-derived, and proatherogenic toxins in sixty patients affected by advanced CKD. After 2 months of a LPD—a reduction in blood urea nitrogen (52 ± 17 vs. 46 ± 15 mg/dL, p = 0.003), total cholesterol (185 ± 41 vs. 171 ± 34 mg/dL, p = 0.001), and triglycerides (194 ± 148 vs. 161 ± 70 mg/dL, p = 0.03) was observed; 57 subjects were then randomized to receive probiotics or a placebo for the subsequent 3 months. A total of 27 patients in the placebo group showed increased serum values of total cholesterol (169 ± 36 vs. 185 ± 40 mg/dL, p = 0.01), LDL cholesterol (169 ± 36 vs. 185 ± 40 mg/dL, p = 0.02), lipoprotein-associated phospholipase $A_{2}$ (155.4 ± 39.3 vs. 167.5 ± 51.4 nmol/mL/min, p = 0.006), and indoxyl-sulphate (30.1 ± 17.6 vs. 34.5 ± 20.2 μM, p = 0.026), while the 24 subjects in the probiotics group showed a trend in the reduction of microbiota toxins. A reduction of antihypertensive and diuretic medications was possible in the probiotics group. This study shows that associating probiotics to LPD may have an additional beneficial effect on the control and modulation of microbiota-derived and proatherogenic toxins in CKD patients. |
| Starting Page | 1637 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu14081637 |
| Journal | Nutrients |
| Issue Number | 8 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-14 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Urology and Nephrology Low Protein Diet Chronic Kidney Disease Gut Microbiota Microbial Uremic Toxins Probiotics Ecologic Therapy Green Nephrology |
| Content Type | Text |
| Resource Type | Article |
