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Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells
| Content Provider | MDPI |
|---|---|
| Author | Trejo-Solis, Cristina Escamilla-Ramirez, Angel Jimenez-Farfan, Dolores Castillo-Rodriguez, Rosa Angelica Flores-Najera, Athenea Cruz-Salgado, Arturo |
| Copyright Year | 2021 |
| Description | The Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation and apoptosis both through β-catenin-dependent and independent mechanisms, and by crosstalk with other signaling pathways in a wide range of malignant tumors. Existing studies have reported conflicting results, indicating that the Wnt signaling can have both oncogenic and tumor-suppressing roles, depending on the cellular context. This review summarizes the available information on the role of the Wnt/β-catenin pathway and its crosstalk with other signaling pathways in apoptosis induction in cancer cells and presents a modified dual-signal model for the function of β-catenin. Understanding the proapoptotic mechanisms induced by the Wnt/β-catenin pathway could open new therapeutic opportunities. |
| Starting Page | 871 |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph14090871 |
| Journal | Pharmaceuticals |
| Issue Number | 9 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-28 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceuticals Oncology Crosstalk Β-catenin Apoptosis Signaling Cancer Cells |
| Content Type | Text |
| Resource Type | Article |
