NDLI: Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

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Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

Content Provider	MDPI
Author	Martin, Darius Sibuyi, Nicole Dube, Phumuzile Fadaka, Adewale Cloete, Ruben Onani, Martin Madiehe, Abram Meyer, Mervin
Copyright Year	2021
Description	The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB diagnostic approaches, such as the culture, sputum smear, skin tuberculin, and molecular tests are time-consuming, and some are unaffordable for low-income countries. Rapid tests for disease biomarker detection are mostly based on immunological assays that use antibodies which are costly to produce, have low sensitivity and stability. Aptamers can replace antibodies in these diagnostic tests for the development of new rapid tests that are more cost effective; more stable at high temperatures and therefore have a better shelf life; do not have batch-to-batch variations, and thus more consistently bind to a specific target with similar or higher specificity and selectivity and are therefore more reliable. Advancements in TB research, in particular the application of proteomics to identify TB specific biomarkers, led to the identification of a number of biomarker proteins, that can be used to develop aptamer-based diagnostic assays able to screen individuals at the point-of-care (POC) more efficiently in resource-limited settings.
Starting Page	1352
e-ISSN	20754418
DOI	10.3390/diagnostics11081352
Journal	Diagnostics
Issue Number	8
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-07-28
Access Restriction	Open
Subject Keyword	Diagnostics Microbiology Tuberculosis Aptamers Lateral Flow Assays Point-of-care Biomarkers
Content Type	Text
Resource Type	Article

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