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SARS-CoV-2 Infection of Unvaccinated Liver- and Kidney-Transplant Recipients: A Single-Center Experience of 103 Consecutive Cases
| Content Provider | MDPI |
|---|---|
| Author | Hardgrave, Hailey Wells, Allison Nigh, Joseph Osborn, Tamara Klutts, Garrett Krinock, Derek Rude, Mary Katherine Bhusal, Sushma Burdine, Lyle Giorgakis, Emmanouil |
| Copyright Year | 2022 |
| Description | Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared a pandemic in March 2020. Its reported impact on solid-organ-transplant-recipient morbidity and mortality has varied. The aim of this study was to present the effect of transplant status, patient comorbidities and immunosuppression modality on the survival of solid-organ-transplant recipients who contracted SAR-CoV-2 during the pre-vaccination era, at a single academic transplant center. Patients (n = 103) were assessed for 90-day mortality. A univariate analysis identified an age of over 60 years (HR = 10, p = 0.0034), Belatacept (HR = 6.1, p = 0.022), and Cyclosporine (HR = 6.1, p = 0.0089) as significant mortality risk factors; Tacrolimus was protective (HR = 0.23, p = 0.022). Common metabolic comorbidities (hypertension, diabetes, obesity) did not stand out as risk factors in our patient cohort. This study on the unvaccinated is expected to facilitate a paired comparison of outcomes in transplanted patients who contracted SARS-CoV-2 during the latter period of the pandemic, when broad SARS-CoV-2 vaccination and novel antibody treatments became broadly available. |
| Ending Page | 207 |
| Page Count | 8 |
| Starting Page | 200 |
| e-ISSN | 26733943 |
| DOI | 10.3390/transplantology3020021 |
| Journal | Transplantology |
| Issue Number | 2 |
| Volume Number | 3 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-16 |
| Access Restriction | Open |
| Subject Keyword | Transplantology Transplantation Solid-organ Transplant Covid-19 Unvaccinated Immunosuppression |
| Content Type | Text |
| Resource Type | Article |
